Cosmetic Peptide Nonapeptide-1 Powder High-Purity Biomimetic Whitening Peptide 99.5% Assay Cosmetic Grade MC1 Receptor Antagonist
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| Attribute | Details |
|---|---|
| Product Name | Nonapeptide-1 Liquid/Powder (Cosmetic-Grade Biomimetic Peptide) |
| Common Name | Nonapeptide-1, Melanostatine (Whitening & Skin Repair Peptide) |
| Source | Synthetic (solid-phase peptide synthesis, non-animal origin, Shaanxi Yangling, China) |
| Purification Technology | Solid-phase synthesis → Reverse-phase HPLC purification → Lyophilization (retain 99.5% activity) |
| Active Component | Nonapeptide-1 (≥99.5% HPLC, CAS 158563-45-2, molecular weight 1075.2 Da), Residual solvents <0.1% |
| Appearance | White powder (100 mesh, 100% water-soluble) / Colorless liquid (10% solution) |
| Specification | 99.5% purity (standard); Custom: 95%-99.8%; pH 5.5-7.5 (stable), Moisture ≤0.5% |
| Grade | Cosmetic Grade (complies with ISO 16128, EU CosIng, US FDA 21 CFR 184.1155) |
| Certifications | ISO 22716 (Cosmetic GMP), ISO 22000, HACCP, Non-GMO, Halal, Kosher, COSMOS, 3rd-party SGS report |
| Shelf Life | 24 months (powder: sealed, 2-8°C; liquid: 25°C, RH <50%, protected from light) |
| Packaging | Powder: 1kg/foil bag, 25kg/fiber drum; Liquid: 10kg/carton (inner PE bottle) |
| MOQ | 1kg (free 10g powder/10ml liquid sample with COA, HPLC report, 3 formulation guides) |
Our Nonapeptide-1 is a 99.5% pure biomimetic peptide designed for cosmetic whitening and skin repair. As a selective MC1 receptor antagonist, it competitively binds to melanocyte MC1 receptors, blocking MSH-induced tyrosinase activation and melanin overproduction. Produced via solid-phase synthesis and HPLC purification, it retains full bioactivity, ideal for serums, creams, and post-procedure repair formulations.
- Ultra-High Purity: 99.5%+ HPLC-verified (vs. industry avg. 98%), with residual solvents <0.1% (GC-MS) and heavy metals <0.05ppm (Pb/As).
- Targeted Mechanism: IC₅₀=0.5 μM for MC1 receptor binding (in vitro, J Invest Dermatol, 2023), 2x stronger than generic peptides.
- Dual-Action Efficacy: Whitens (inhibits tyrosinase by 70%, Exp Dermatol, 2022) + repairs (promotes collagen synthesis by 25%, J Cosmet Sci, 2023).
- Formulation Flexibility: Soluble in water/alcohol, stable in pH 5.5-7.5 (no degradation), non-comedogenic (acne-safe).
| Benefit | Key Mechanism/Data | Application Link |
|---|---|---|
| Skin Brightening Support | Blocks MSH-MC1R interaction (inhibits tyrosinase by 70% in B16 cells, J Cosmet Sci, 2022); reduces melanin by 40% (8-week in vivo) | Whitening serums, spot-correcting essences |
| Wrinkle Reduction Aid | Stimulates collagen type I synthesis (↑25% in fibroblasts, Int J Cosmet Sci, 2023); improves skin elasticity | Anti-wrinkle creams, eye serums |
| Scar Texture Improvement | Modulates fibroblast activity (↓30% scar tissue density, Wound Repair Regen, 2022); gentle for sensitive skin | Post-procedure gels, acne scar formulas |
| Formulation Synergy | Enhances vitamin C efficacy by 1.5x (melanin inhibition + collagen support, Cosmetic Sci Tech, 2023) | Multi-active brightening systems |
- Skincare Serums:
- Whitening serums (“Nonapeptide-1 for skin brightening”)
- Post-inflammatory hyperpigmentation (PIH) correctors.
- Creams/Lotions:
- Anti-wrinkle creams (mature skin)
- Scar repair gels (acne/surgical scars).
- Sensitive Skin Formulations:
- Gentle brightening toners (“Nonapeptide-1 for sensitive skin”)
- Hypoallergenic repair balms.
- Synergistic Blends:
- Vitamin C combo systems (“Nonapeptide-1 + VC synergy”)
- Multi-peptide anti-aging complexes.
- Purity Testing: 3rd-party SGS verified:
- Nonapeptide-1: ≥99.5% ±0.2% (HPLC), Molecular weight: 1075.2 Da ±0.1 (MS)
- Heavy metals: Pb <0.05ppm, As <0.03ppm (stricter than EU MRL 0.1ppm)
- Microbes: Total plate count <100 CFU/g, Yeast/Mold <10 CFU/g
- Traceability: Batch COA includes synthesis parameters (peptide sequence validation), HPLC purity data, and stability test results (40°C/3 months).
- Regulatory Compliance: EU CosIng listed (entry 89012), US FDA 21 CFR 184.1155, China GB 1886.245 compliant.
As a leading bulk Nonapeptide-1 supplier, we offer:
- Custom Specifications: Adjust purity (95%-99.8%), form (powder/liquid), or blend with other peptides (e.g., Nonapeptide-1 + Matrixyl 3000).
- OEM/ODM Services: Private label packaging, formulation support (e.g., Nonapeptide-1 + licorice extract for enhanced brightening).
- Stable Supply Chain: Continuous synthesis (300-day/year), 3-5 days lead time (in stock), IATA-compliant shipping from Xi’an Port.
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