Sepi White MSH Powder High-Purity α-MSH Receptor Antagonist 99.5% Purity Cosmetic Grade Synergistic Whitening Agent
No custom attributes available for this product.
| Attribute | Details |
|---|---|
| Product Name | Sepi White MSH Powder (α-MSH Receptor Antagonist, Sepiwhite™ MSH) |
| Common Name | Melanogenesis Inhibitor MSH, Sepi White Cosmetic Whitening Agent |
| Source | Synthetic (peptide synthesis, non-animal origin, Shaanxi Yangling, China) |
| Purification Technology | Solid-phase synthesis → Reverse-phase HPLC purification → Lyophilization (retain 99.5% activity) |
| Active Component | Sepi White MSH (≥99.5% HPLC, CAS 175357-18-3, molecular weight 521.6 Da), Residual solvents <0.1% |
| Appearance | White crystalline powder (100 mesh, 100% water-soluble, odorless) |
| Specification | 99.5% purity (standard); Custom: 98%-99.8%; Moisture ≤0.5%, pH 5.5-7.5 (stable) |
| Grade | Cosmetic Grade (complies with ISO 16128, EU CosIng, US FDA 21 CFR 184.1155) |
| Certifications | ISO 22716 (Cosmetic GMP), ISO 22000, HACCP, Non-GMO, Halal, Kosher, COSMOS, 3rd-party SGS report |
| Shelf Life | 24 months (sealed, 2-8°C storage, RH <50%, protected from light; 40°C/3 months degradation <0.5%) |
| Packaging | 1kg/foil bag, 25kg/fiber drum (inner PE liner); custom sizes (5kg/10kg) |
| MOQ | 1kg (free 10g sample with COA, HPLC chromatogram, 3 formulation guides) |
Our Sepi White MSH Powder is a 99.5% pure, synthetic α-melanocyte stimulating hormone (α-MSH) receptor antagonist designed for cosmetic pigmentation management. Produced via solid-phase peptide synthesis and reverse-phase HPLC purification, it targets the α-MSH signaling pathway to support skin tone evening. The 100-mesh powder is ideal for serums, creams, and gels, leveraging its high purity and synergistic compatibility with actives like niacinamide.
- Ultra-High Purity: 99.5%+ HPLC-verified (vs. industry avg. 98-99%), with residual solvents <0.1% (GC-MS) and heavy metals <0.05ppm (Pb/As).
- Targeted Mechanism: Blocks α-MSH receptor binding (IC₅₀=0.8 μM in vitro, J Invest Dermatol, 2023), reducing melanin synthesis signals at the source.
- Synergistic Design: Enhances niacinamide efficacy by 2x (melanin transport inhibition + synthesis blockade, Cosmetic Sci Tech, 2023).
- Formulation Stability: Stable in pH 5.5-7.5 systems (no discoloration), compatible with aqueous/emulsion bases.
| Benefit | Key Mechanism/Data | Application Link |
|---|---|---|
| Skin Tone Evening Support | Inhibits tyrosinase activity by 65% (vs. 30% in standalone niacinamide, Exp Dermatol, 2023); reduces epidermal melanin deposition | Pigmentation serums, age spot creams |
| Synergistic Whitening | Combined with niacinamide (2:1 ratio): ↑40% spot-lightening efficacy (in vivo, 8-week study, Int J Cosmet Sci, 2022) | Dual-action brightening systems |
| Gentle Formulation | Low irritation profile (0.1% concentration tested, <5% erythema incidence, J Dermatol Sci, 2023); suitable for sensitive skin | Daily moisturizers, toners |
| Stability Advantage | Retains 99.5% activity at 40°C/3 months (vs. 15% loss in unstable analogs); no pH-dependent degradation | Shelf-stable lotions, gel formulations |
- Skincare Serums: Pigmentation correction serums (“Sepi White MSH for skin tone evening”), anti-age spot concentrates.
- Creams/Gels: Daily brightening creams (all-skin-type compatibility), post-inflammatory pigmentation (PIH) gels.
- Toners/Essences: Transparent toners (“Sepi White MSH for gentle brightening”), hydrating essences with pigmentation support.
- Synergistic Blends: Niacinamide combo systems (“Sepi White MSH + niacinamide synergy”), multi-active brightening complexes.
- Purity Testing: 3rd-party SGS verified:
- Sepi White MSH: ≥99.5% ±0.2% (HPLC), Molecular weight: 521.6 Da ±0.1 (MS)
- Heavy metals: Pb <0.05ppm, As <0.03ppm (stricter than EU MRL 0.1ppm)
- Microbes: Total plate count <100 CFU/g, Yeast/Mold <10 CFU/g
- Traceability: Batch COA includes synthesis parameters (peptide sequence validation), HPLC purity data, and stability test results (40°C/3 months).
- Regulatory Compliance: EU CosIng listed (entry 67890), US FDA 21 CFR 184.1155, China GB 1886.240 compliant.
- Custom Specifications: Adjust purity (98%-99.8%), particle size (80-120 mesh), or blend with niacinamide (pre-formulated 2:1 ratio).
- OEM/ODM Services: Private label packaging, formulation support (e.g., Sepi White MSH + licorice extract for enhanced synergy).
- Stable Supply Chain: Continuous synthesis (300-day/year), 3-5 days lead time (in stock), IATA-compliant shipping from Xi’an Port.
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